Stelis bricenorum, a new species from the Municipality of Guainía, Amazonas state, Venezuela, is described and illustrated. It has been collected both in the Rio Negro (and therefore the Amazon, along the Yavita-Maroa road) and Orinoco river (“caño Chimita”, affluent of the Atacavi river) basins. Stelis bricenorum is similar to S. santiagöensis, from which it can be easily distinguished by its relatively smaller habit, the wider sepals, and the glabrous petals.